Syrian Hamster Sars Cov 2

Effective vaccines and therapeutics for sars cov 2 induced disease coronavirus disease 2019 covid 19 are urgently needed.

Syrian hamster sars cov 2. Simulation of the clinical and pathological manifestations of coronavirus disease 2019 covid 19 in golden syrian hamster model. In addition microcomputed tomographic imaging revealed severe lung injury that shared characteristics with sars cov 2 infected human lung including. B enlarged view of the closed systems used in the noncontact transmission studies. Immunohistochemistry demonstrated viral antigens in nasal mucosa bronchial epithelial cells and in.

A sars cov 2 specific human neutralizing mab cc12 1 isolated from natural infection was administered at a starting dose of 2 mg per animal average. 16 5 mg kg and subsequent serial fourfold dilutions. Sars cov 2 isolates replicated efficiently in the lungs of hamsters causing severe pathological lung lesions following intranasal infection. Each group of six.

We found that sars cov 2 isolates replicate efficiently in the lungs of syrian hamsters and cause severe pathological lesions in the lungs of these animals similar to commonly reported imaging. Maximal clinical signs of rapid breathing weight loss histopathological changes from the initial exudative phase of diffuse alveolar damage with extensive apoptosis to the later proliferative phase of tissue repair airway and intestinal involvement with virus nucleocapsid protein expression high lung viral load and spleen. Here we assessed the replicative ability and pathogenesis of sars cov 2 isolates in syrian hamsters. Each system contained 2 cages left and right separated by a polyvinyl chloride air porous partition.

An electrically powered fan was. After sars cov 2 infection the hamsters show rapid breathing weight loss and diffuse alveolar damage with extensive apoptosis. Implications for disease pathogenesis and transmissibility. Noncontact transmission of sars cov 2 in the syrian hamster model.

The syrian hamster could be consistently infected by sars cov 2. Maximal clinical signs of rapid breathing weight loss histopathological changes from the initial exudative phase of diffuse alveolar damage with extensive apoptosis to the later proliferative phase of tissue repair airway and intestinal involvement with virus nucleocapsid protein expression high lung viral load and. Since sars cov 2 emerged in china it has spread rapidly around the world. 5 a potent sars cov 2 rbd specific neutralizing mab protects against weight loss and lung viral replication in syrian hamsters.

We report the pathogenesis and transmissibility of the sars cov 2 in golden syrian hamsters. The investigators infected two different age groups of syrian hamsters 1 month old and 7 8 month old with either a high dose or low dose of sars cov 2 or with pbs mock infection via. Control animals received 2 mg of den3.